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KMID : 1098420090170050357
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Korean Journal of Medicinal Crop Science
2009 Volume.17 No. 5 p.357 ~ p.362
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α-Glucosidase and α-Amylase Inhibitory Activity of Compounds from Roots Extract of Pueraria thunbergiana
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Park Jee-Hee
Baek Mok-Ryeon
Lee Byung-Hoi
Yon Gyu-Hwan
Ryu Shi-Yong
Kim Young-Sup
Park Sang-Un
Hong Kyung-Sik
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Abstract
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Compounds of isolated from roots extract of Pueraria thunbergiana were tested their inhibitory effects on α- glucosidase and α-amylase. Inhibitory activity of methylene chloride (MC) fraction and ethyl acetate (EA) fraction against α-glucosidase showed more than 60% at a concentration of 500㎍/㎖. Among the nine compounds tested on α-glucosidase, biochanin A, (?)-tuberosin and calycosin from MC fraction and daidzein from EA fraction were stronger inhibitors than acarbose (IC50 = 530㎍/㎖), and their IC50 were 9, 144, 328 and 20㎍/㎖, respectively. Biochanin A and (?)-tuberosin also inhibited α-amylase activity as like as acarbose IC50 = 20.5 ㎍/㎖), and their IC50 were 22 and 348 ㎍/㎖, respectively. Although daidzein was already known α-glucosidase inhibitory effects, it was newly evaluated that biochanin A and (?)- tuberosin inhibited α-glucosidase as well as α-amylase, and that calycosin did α-glucosidase.
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KEYWORD
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Pueraria thunbergiana, α-glucosidase, α-amylase, biochanin A, (-)-tuberosin
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